The relative importance of Endogenously Secreted incretin hormones, <scp>GLP</scp> ‐1 and <scp>GIP</scp> for Postprandial Glucose Tolerance and <scp>β‐Cell</scp> Function After <scp>Roux‐en‐Y</scp> Gastric Bypass and Sleeve Gastrectomy Surgery

Bariatric surgery procedures, namely Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) is increasingly used worldwide, have been shown to be the most effective strategy induce maintain weight loss as well inducing long-term remission from type 2 diabetes among people with significant obesity. The mechanism for remains unclear multi-factorial, although increased secretion of endogenous glucagon-like peptide 1 (GLP-1) hormones improve postprandial β-cell function widely considered main following RYGB. However, recent studies that rate between two types bariatric procedures are similar but yet, above beyond per se SG less clear. Beyond GLP-1, role other major incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), relatively unexplored after surgery. A study published in Diabetes Care therefore studied effects separate combined GLP-1 receptor (GLP-1R) GIP (GIPR) blockade during mixed-meal tests un-operated (CON), SG-operated, RYGB-operated no history diabetes. investigator found that, expected, concentrations were highest RYGB also higher compared CON. In contrast, lowest Interestingly, blockage GLP-1R reduced glucose sensitivity responses both surgical groups had effect Blockage GIPR however CON group. This showed while important mediator improved beta cell RYGB, equally SG. combine benefits interesting, given emergence dual agonist treatment It would interesting explore relative Glucagon on procedures.